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Central sensitization: Implications for the diagnosis and treatment of pain
26.02.2018 Clifford J Woolf, Program in Neurobiology and FM Kirby Neurobiology Center, Children’s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, Ma. Abstract Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity,…
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Sympathetic nervous system and pain
A clinical overview of the autonomic nervous system, the supply to the gut and mind–body pathways LOUIS GIFFORD AND MICK THACKER Introduction The autonomic nervous system (ANS) is an ‘output’, ‘effector’ or ‘motor’ system (see Gifford 1998b)—i.e. it responds to the demands of the sensory systems and the central nervous system (CNS) by producing an…
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Entrapment of middle cluneal nerves as an unknown cause of low back pain
CASE REPORT In April 2013, a 48-year-old woman presented complaining of LBP and buttock pain radiating to both legs that had gradually developed over 10 years. L4-5 discectomy performed at another hospital two years before resulted in no improvement. The pain was continuous and severe even with long-term daily use of tramadol 225 mg/acetaminophen 1950…
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Perspectives: practical application of clinical neurophysiology
About the ArticleRegular publications, RMJ № 7 of 23.07.2018 pp. 37-40Section: NeurologyAuthors: Palomar H.1, Isaikin A.I.2, Svet M.S.1, Alekseev A.V.3 1 “P-DTR Rehabilitation and research center”, Geneva, Switzerland2 Sechenov State Medical University, Moscow3 LLC “Med-UrConsult”, Moscow Abstract The practical healthcare during recent decades has been marked by the growing popularity of evidence-based medicine when determining methods or means of treatment and/or medical…
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Nociception Affects Motor Output: A Review on Sensory-motor Interaction With Focus on Clinical Implications
Nociception Affects Motor Output A Review on Sensory-motor Interaction With Focus on Clinical Implications Jo Nijs, PT, MPT, PhD, Liesbeth Daenen, PT, MSc, Patrick Cras, MD, PhD, JFilip Struyf, PT, MSc, Nathalie Roussel, PT, MPT, PhD, and Rob A.B. Oostendorp, PT, MPT, PhD Objectives: Research has provided us with an increased understanding of nociception-motor interaction. Nociception-motor…
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Peripheral and central viewpoints of chronic pain, and translational implications
A. Vania Apkariana,b,c,⁎, Diane Reckziegelaa Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USAb Department of Anesthesia, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USAc Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611,…
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Nociception, Pain, Negative Moods, and Behavior Selection
07.02.2020Marwan N. Baliki1,* and A. Vania Apkarian1,2,3,*1Department of Physiology2Department of Anesthesia3Department of Physical Medicine and RehabilitationFeinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60610, USA*Correspondence: m-baliki@northwestern.edu (M.N.B.), a-apkarian@northwestern.edu (A.V.A.)http://dx.doi.org/10.1016/j.neuron.2015.06.005 Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk for developing chronic pain. Within this context, we revisit the concepts for nociception, acute…
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Chapter 2: Spinal Reflexes and Descending Motor Pathways
2.1 Spinal Reflexes As noted in the previous chapter, a sense of body position is necessary for adaptive motor control. In order to move a limb toward a particular location, it is imperative to know the initial starting position of the limb, as well as any force applied to the limb. Muscle spindles and Golgi…
